Plataformas Genómicas
Plataformas Genómicas

Genomic platform

pruebas genómicas

Thanks to molecular biology we can analyse what tumours have, that normal cells do not have, and take advantage of these mechanisms to design treatments that exclusively target these alterations rather than targeting healthy cells.
 
Genomic testing is the foundation of precision medicine. Having greater knowledge regarding the nature of different types of tumours shows us which treatments will be more specific and therefore more effective and less toxic for the patient.

Biomarker or genomic testing analyses tumour cells at a molecular level, determining the type of abnormality present in the tumour, so that personalised therapeutic decisions can be made.  
Although two tumours of the same location look the same when viewed under a microscope, their genetic abnormality may be different, as a result they will not react to treatment in the same way.
 
Identifying these alterations opens up a range of new drugs aimed at these specific mutations.

Cuándo esta indicado las pruebas genómicas
An increasing number of patients can benefit from these tests, daily advances in molecular medicine are identifying new therapeutic targets in tumours.
 
Cancers that would currently benefit from these tests are breast, lung, prostate, ovarian and colon cancers.
 
Specifically, cancer treatment should not be prescribed in patients with advanced or metastatic lung cancer until it has been confirmed whether or not the patient may benefit from personalised treatment.
 
New genes which appear in several types of tumours are gradually being discovered, as a result it is anticipated that in future applying this technique to virtually all types of tumour will be possible.

biopsaia liquida
There are two ways to perform genomic testing:
 

  • Using a tumour sample This is carried out using a stored sample of the biopsy taken at the time of diagnosis. With a small amount of tumour material we can determine up to 400 gene mutations that the tumour may have.
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  • Liquid biopsy: Through a blood test from the patient we can analyse the genetic material shed by the tumour into the blood. It is a slightly less sensitive technique but is widely used when the stored specimen cannot be used or the sample is insufficient

Thanks to the information provided by genomic tests, we can:
 

  • Design increasingly accurate treatment, targeted at a specific abnormality.
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  • Personalise treatment for each patient
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  • Offer less toxic treatment as it only affects tumour cells rather than normal cells,
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  • Improve effectiveness whilst having far fewer side effects
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  • Prolong patient survival and offer a better quality of life.
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  • FoundationOne®: test for characterisation of mutations and search for targeted therapeutic treatments for solid tumours in a tumour biopsy sample. It allows a search for targeted therapies for the abnormalities found.
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  • Foundation One Heme® test for characterisation of mutations and search for targeted therapeutic treatment for haematological malignancies, sarcomas and some paediatric tumours.
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  • Foundation ACT®: diagnostic genetic test ondiagnostic genetic test on blood samples (Liquid Biopsy) when no tumour tissue is available, mutation sequencing and therapeutic targets. It allows a search for targeted therapies using the abnormalities found in tumours without sufficient biological sample,. when no tumour tissue is available, mutation sequencing and therapeutic targets. It allows a search for targeted therapies using the abnormalities found in tumours without sufficient biological sample.
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  • MammaPrint®: mutation sequencing in early-stage breast cancer to safely determine risk of relapse and whether or not chemotherapy is needed.
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  • Oncotype DX®: mutation sequencing in early-stage breast cancer to safely determine the risk of relapse and whether or not chemotherapy is needed.
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  • Prosigna®: mutation sequencing in early-stage breast cancer to safely determine the risk of relapse and whether or not chemotherapy is needed.
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  • OncotypeDX Colon Recurrence Score®:test for mutation characterisation and search for therapeutic targets in solid tumours in a tumour biopsy sample. It allows the search for targeted therapies on the abnormalities found.
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  • ONCODEEP TM: test for mutation characterisation and search for therapeutic targets in solid tumours in a tumour biopsy sample. It allows the search for targeted therapies on the abnormalities found.
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  • GUARDANT 360: genomic blood tests (Liquid Biopsy).

Oncology Consultants

Dr. Ponce Aix, Santiago
Medical Oncology Specialist
Clinical Dedication in Lung Cancer
Precision medicine
Cancer immunotherapy

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