It is a fundamental part of multidisciplinary cancer management, with the capacity to destroy cancer cells and prevent their growth and reproduction.
 
Radiotherapy is a local treatment, therefore only affecting the part of the body which is targeted.
 
Both the preparation and application of treatment require very complex technology. This technology has advanced greatly in the last few decades allowing more precise and safe radiotherapy treatment to be offered, greatly reducing possible side effects.

• 1. It eradicates/destroys disease:
   
  In established locations, when disease has still not spread, radiotherapy can eradicate the tumour, either alone or in conjunction with other treatments (systemic treatment).

 

• 2. It controls/stabilises the tumour:
   
  In more advanced tumours, or in those which have spread to other parts of the body, radiotherapy can stabilise disease and prevent the tumour from growing further and invading other structures.
   
  Although it does not make the tumour disappear completely it can shrink it, making surgery easier.

 

• 3. It alleviates cancer symptoms:
   
  When the disease has already spread and is also causing symptoms affecting the patient’s quality of life (whether that be pain, bleeding or neurological or respiratory abnormalities), radiotherapy treatment may be suggested for symptom control.

A linear accelerator generates a high amount of energy (electrons). These electrons are accelerated, colliding with a target, causing high energy X-rays. These X-rays target the treatment zone, damaging DNA and causing cell death in the tumour cells, preventing their reproduction and spread. During this process, the patient cannot see, smell or feel the radiotherapy, as we often say, “you just have to believe”.
 
Neither do patients go home with radiation in their body, allowing them to continue to be with children or pregnant women following treatment.
 
Radiotherapy is generally well tolerated and is given on an outpatient basis. Although treatment requires several sessions, the latest technological advances have meant treatments are becoming shorter and shorter, whilst still being equally effective.
 

 
Ionising radiation causes breaks in the DNA molecules, damaging their function, encouraging cell death and destroying their capacity to reproduce.
 
Cancer cells are slightly more sensitive to radiation than healthy cells.
 
Treatments are programmed with submillimetre precision, with the aim of affecting the tumour cells whilst reducing the dose to healthy tissue as much as possible.
 

70% of oncology patients will require radiotherapy.
 
Radiotherapy treats cancer at its source and the aim varies depending on when it is given.
 
Radiotherapy treats cancer at its source and the aim varies depending on when it is given.
 

• Exclusive radiotherapy: As a single curative treatment.

 

• Adjuvant radiotherapy:This is given after a different radical treatment, such as surgical treatment, to eliminate possible microscopic residual disease.

 

• Preoperative radiotherapy: This is given before local, radical surgical treatment to attempt locoregional reduction of the disease, with the aim of enabling more conservative surgery. A common location for this is preoperative treatment of cancer of the rectum, to allow preservation of the sphincter.

 

• Concomitant/sequential radiotherapy: When combined with another systemic treatment, this enables simultaneous treatment of local disease and possible micrometastasis, using sensitisation of tissues to ionising radiation (radiosensitisation treatment).

 

• Concomitant/sequential radiotherapy: This is used for symptom control, for example, when the tumour has grown and is pressing on any region causing pain.

The duration of treatment from when the patient enters the machine until they leave usually lasts around 20-25 minutes. This period of time includes:
 

• positioning of the patient,
• establishment of the parameters of the machine,
• image taking for checking and verification,
• application of treatment and
• finally helping the patient to sit up and then leave.

 
In other words, the irradiation itself only lasts around 2-5 minutes. There are patients whose positioning may take more time due to their physical condition, or due to tumours which have undergone changes during treatment, making verification more complex.

Treatment is always individualised, in other words, each patient has their own specific treatment, which differs to any other patient.
 
Giving ionising radiation for therapeutic reasons requires a laborious technical and clinical process.
 
Following the first consultation with the radiotherapy oncologist, where treatment is explained to the patient, preparation for radiotherapy treatment begins and involves several phases:

Depending on the aim of treatment (curative/palliative) the expected response will be at a clinical, symptomatic level, or at a radiological level. As radiotherapy causes changes in cells, it does not have an immediate effect, on occasion a reduction in size or changes in tumour can continue to be seen even months after treatment.
 
When we want to achieve symptomatic relief, then we see the response as pain relief, cessation of bleeding or recovery of function.
 
However, when the intention is to eradicate or control disease, an initial imaging study (CT, MRI or PET-CT) is indicated at 2-3 months after finishing treatment, to compare the size and activity of the tumour in relation to tests prior to treatment. Following on, monitoring is then performed following an initial period of 3-6 months to check response to treatment. An imaging study is not indicated as soon as treatment finishes as oedema/inflammation will probably be seen and/or a lack of response. There are times when a response is seen during treatment, a reduction in tumour size may be seen on the daily image monitoring prior to each session.

Throughout our lives we are exposed to many types of radiation. For the most part it is environmental, coming from natural sources such as the earth on which we live, the sun, the air we breathe, the water and the food we consume.
 
The whole radiotherapy department relies on special radiological protection measures which ensure that the radiation dose absorbed by our centre’s personnel is at a minimum.
 
The staff who have most contact with the radiotherapy department are obliged to carry a dosimeter which guarantees that the dose of radiation absorbed is not dangerous and is within established limits.
 
The accelerator only emits radiation when it is in use. Once the patient leaves the machine they are not left with any radiation in their body and can therefore continue to be with children and pregnant women without any risk.

The accelerator is within a bunker with concrete walls which are 1.5 m thick and comply with very strict technical specifications, as indicated by the Nuclear Safety Council. The council verifies the installation and gives the go ahead and authorisation on behalf of the Ministry for the Ecological Transition.
 
Within the Radiotherapy Department there is a Quality Assurance Committee, responsible for developing an assurance plan, to comply and inform the competent authorities of any error.
 
The radiophysicist continually checks that the condition of the machine is optimal and that there is no risk.
 
Our accelerator is also monitored by its manufacturer in Madison, USA.